00:01
Now we want to take a look at the differences
in skin color.
00:05
Looking at the epidermis, the melanocytes,
the dermis and hair.
00:11
If we focus on the epidermis, what are some
of the differences in melanin rich and
melanin poor skin types.
00:20
On the epidermis.
00:23
So if you look at the stratum corneum as
part of the epidermis, as we have spoken
about that in our previous lectures, in
light skin or melanin poor skin, there's
about 17 cell layers.
00:38
However, the dark skin has got about 22 cell
layers.
00:43
Same thickness, but then the cells are more
compact in dark skin.
00:51
So, as explained, because of the thicker
layers in the dark skin, it makes it stronger
when exposed to mechanical or chemical
stress.
01:04
The other second difference is increased
transepidermal water loss and decreased
ceramides. This will also find in people
with melanin rich skin.
01:20
So the combination of increased
transepidermal water loss and decreased
ceramides make the skin more prone to
dehydration and make the skin drier.
01:35
And this can lead to a condition called
xerosis, which means dry skin.
01:41
And xerosis and atopic dermatitis are also
seen more commonly in melanin rich skin.
01:49
The second point I want to talk about in
terms of the differences between melanin rich
and melanin poor skin, is melanocytes and
the melanin.
02:01
The number of melanocytes is the same in all
skin types.
02:07
The main difference is in the melanosomes
and melanin.
02:12
So physiologically, anatomically the skin is
the same.
02:16
But the difference that gives us our
different skin color is the melanosomes and
melanin. We are now going to zoom in on
melanosomes to try and find out what are the
differences between the two skin types in
light skin.
02:30
The lower number of melanosomes in dark
skin.
02:33
There's a higher number of melanosomes in
light skin.
02:36
They are small and aggregated, and in dark
skin they are larger and non-aggregated.
02:41
They are mostly confined to the basal layer,
whereas in dark skin they are distributed
throughout the epidermis, as you can see on
that picture, there's a faster degradation
rate in light skin and a lot slower
degradation rate in dark skin.
02:55
So now I want to talk about melanin in light
skin.
02:58
We've got a lower melanin content.
03:00
And in dark skin we've got a higher melanin
content.
03:03
And of course a lower rate of melanogenesis
compared to dark skin due to the previously
mentioned properties.
03:11
Talking about melanosome size and melanin
content, the dark skin provides better
photoprotection five times less UV light
reaches the upper dermis in black skin
compared to a lighter skin.
03:25
So the advantages of higher photoprotection
in dark skin.
03:29
One of the advantages, actually, is that you
tend to get delayed aging and reduced
wrinkling in patients with melanin rich
skin.
03:39
This picture here shows you a 70 year old
female African patient and a white patient,
and you can obviously see the difference in
photoaging between these two.
03:50
And this is all due to the fact that
Africans have got darker skin with more
melanin, more melanosomes, and of course,
more photoprotection.
04:01
The other advantage is the lower risk of
skin cancer that you find in patients with
dark skin. The disadvantage, though, is the
fact that when you have more melanin and an
increased number of melanosomes, you tend to
get a greater risk of pigmentation
alteration. And this you tend to see after
inflammation, something that we called we
call post-inflammatory hyperpigmentation.
04:30
There's also a higher risk for vitamin D
deficiency, which leads to reduced UVB light
penetration and reduced vitamin D
production.
04:40
We're moving on now to the third difference,
which is focusing on the differences in the
dermis The dark skin has got thick and more
compact dermis compared to lighter skin,
where it's thinner and less compact.
04:54
The papillary and reticular layers, they are
less distinct, whereas in light skin the
papillary and reticular layers are more
distinct.
05:03
So the following are some of the main
differences between dark skin and light skin,
as you can see on the slide.
05:11
I want to touch on the fibroblasts in dark
skin.
05:15
There's numerous large and multinucleated
fibroblasts, whereas in light skin there are
very few fibroblasts.
05:24
Now, again homing down on the fibroblasts.
05:27
These differences in fibroblasts are thought
to be a main factor in keloid formation in
dark skin. In addition to genetics and other
epigenetic factors, the other factors for
keloid formation include decreased
collagenase and a higher number of
melanosomes in dark skin, as we have
mentioned, this is a gentleman who developed
a keloids after acne.
05:53
And this is how sometimes black skin heals
heals with keloids and scars.
05:59
However, if you compare with light skinned
patients acne, you can see the picture on the
left. The patient had acne and healed
beautifully after the inflammation, and this
is the advantage of having less melanin.
06:15
If we move on now to head differences, what
are some of the head differences between
melanin rich and melanin poor skin types?
So if we look at the general classification
of hair of in the following groups the
Asians, Caucasians and Africans.
06:33
This is a lovely table depicting the main
differences in terms of morphology, the
growth rate and density.
06:42
African patients tend to have slightly
higher than Asian in terms of head density,
but the Asians have got the lowest head
density.
06:53
And of course, if you look at the
cross-section of hair, the shape is
different. Looking at the round and uniform
in Asian hair, it's overall in Caucasian hair
and flattened in African hair.
07:05
So what are the classifications of black
hair types?
This is a lovely study that was undertaken
by Lawson.
07:13
Looking at the different hair types from
type one to type eight.
07:18
Type eight being the most curly and coily
type of hair compared to type one which is
straight. Again, focusing on African hair,
it tends to be curly with narrow angles of
twists. It's got a thinner cuticle layer,
and these two features make it more prone to
structural damage and breakage as well as
the formation of complex knots and a high
prevalence of longitudinal splits.
07:53
So the curly shape of africanum makes it
difficult for sebum to travel from the scalp
down the hair shaft. As you can imagine, if
you have a straight coil, it's easy for fluid
to go through compared to something that is
coily, where it has to try and navigate
angles and crevices.
08:12
So the hair tends to be relatively dry
compared to the other skin types.
08:19
So what are some of the implications of
having a natural curly curly African hair?
Well, a condition called pseudofolliculitis
barbae an acne killer, Dallas nuchae is
actually caused by the fact that Africans
have curly hair, and that is a condition that
we see quite commonly amongst African
patients.